Durvalumab plus tremelimumab for the treatment of advanced neuroendocrine neoplasms of gastroenteropancreatic and lung origin

Abstract Single immune checkpoint blockade in advanced neuroendocrine neoplasms (NENs) shows limited efficacy; dual checkpoint blockade may improve treatment activity.Dune (NCT03095274) is a non-randomized controlled multicohort phase II clinical trial evaluating durvalumab plus tremelimumab activity and safety in advanced NENs.This study included

read more

A Novel Multidimensional Statistics Denoising Algorithm Based on Gaussian Mixture Model for Photon-Counting LiDAR Data

The micropulse multibeam photon-counting laser altimeter significantly improves the sampling density along the orbit while introducing abundant noise.Therefore, noise removal is crucial for the subsequent applications of the photon-counting laser altimeter.This study proposes a new multidimensional statistics algorithm based on the Gaussian mixture

read more